INFORM January 2024

36 • inform January 2024, Vol. 35 (1)

provide a concise overview of the types of polyphenols and bio availability determination methods and, subsequently, discuss the concept of conjugation methods, including different synthesizing methods, confirmation procedures, and the effects of conjugation on polysaccharides and polyphenols. Overall, this review provides a comprehensive update on recent advances in conjugation methods that can be used to improve the bioavailability of polyphenols and highlights the potential of these approaches to enhance the health benefits of polyphenol-rich foods. Opportunities and challenges in enhancing the bioavailability and bioactivity of dietary flavonoids: A novel delivery system perspective Yuan, D., et al., Food Chemistry, 430, 137115, 2024. https://doi.org/10.1016/j.foodchem.2023.137115 Flavonoids have multiple favorable bioactivities including antioxidant, anti-inflammatory, and antitumor. Currently, flavo noid-containing dietary supplements are widely tested in clini cal trials for the prevention and/or treatment of multiple diseases. However, the clinical application of flavonoids is largely compro mised by their low bioavailability and bioactivity, probably due to their poor aqueous solubility, intensive metabolism, and low sys temic absorption. Therefore, formulating flavonoids into novel delivery systems is a promising approach for overcoming these drawbacks. In this review, we highlight the opportunities and chal lenges in the clinical use of dietary flavonoids from the perspec tive of novel delivery systems. First, the classification, sources, and bioactivity of dietary flavonoids are described. Second, the prog ress of clinical research on flavonoid-based dietary supplements is systematically summarized. Finally, novel delivery systems devel

oped to improve the bioavailability and bioactivity of flavonoids are discussed in detail to broaden the clinical application of dietary flavonoids. Resveratrol combats chronic diseases through enhancing mitochondrial quality Tao, W., et al., Food Science and Human Wellness, 13, 2, 597, 2024. https://doi.org/10.26599/FSHW.2022.9250140 Resveratrol (RSV), as a functional food component extracted from natural plants, has been widely studied and recognized in preventing and treating various diseases, with major mechanisms including executing anti-inflammation and anti-oxidation func tions, and improving mitochondrial quality. Chronic diseases as non-communicable diseases are mainly caused by multiple fac tors, such as physiological decline and dysfunction in the body, and have become a significant challenge on public health world wide. It is worth noting that chronic diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), muscle atrophy, cardio vascular disease, obesity, and cancer are accompanied by abnormal mitochondrial function. Therefore, targeted regulation of mito chondria may be a meaningful way to prevent and treat chronic diseases. Increasing evidence has confirmed that RSV is actively involved in regulating mitochondria, and it has become an essen tial consideration to prevent and treat chronic diseases through targeting mitochondria and improving corresponding functions. In this article, current studies on RSV to optimize mitochondrial quality for preventing and alleviating chronic disease are system atically summarized, which can provide a theoretical reference for the development of functional foods or drugs to combat chronic diseases.