AAPD Reference Manual 2022-2023

CLINICAL PRACTICE GUIDELINES: PIT AND FISSURE SEALANTS

EVIDENCE PROFILE: POLYACID-MODIFIED RESIN SEALANTS COMPARED WITH RESIN-BASED SEALANTS IN PIT-AND- FISSURE OCCLUSAL SURFACES IN CHILDREN AND ADOLESCENTS *

sTable 6.

QUALITY ASSESSMENT No. of Studies

Study Design Risk of Bias Inconsistency Indirectness

Imprecision Other Considerations

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PATIENTS (N)

EFFECT

QUALITY IMPORTANCE

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* Sources: Gungor and colleagues s22 and Pardi and colleagues. s18 * * Dashes indicate data not available. † The percentages (30% and 70%) indicate the control group baseline risk (caries prevalence). †† Unexplained heterogeneity ( P <.00001, I 2 =97%). ‡ The studies only reported the outcome in patients who were caries-free. No subgroup analysis was conducted. ‡‡ 95% confidence interval suggests a large benefit and a large harm (95% confidence interval, 88% reduction-521% increase). § The 2 studies were classified as "unclear" risk of bias for the domain "allocation concealment". ¶ 95% confidence interval suggests a large benefit and a large harm (95% confidence interval, 52% reduction-114% increase). # 1of 2 studies reported being conducted in water-fluoridated communities.

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